First movie of Anne Curtis was Magic Kingdom where she played a princess. She attended T.G.I.S (Thank God It's Sabado) during her teen life. She had few teleserye in GMA Network. In 2004, she transferred to ABS-CBN. She rose to prominence when she played Stephanie in Hiram along with Geoff Eigenman, Heart Evangelista, Kris Aquino, and Dina Bonnevie, mother of her ex-boyfriend, Oyo Boy Sotto and her close friend, Danica Sotto. After the teleserye, she was given the role of Imang, a kampanerang kuba. It was a remake of the movie, Kampanerang Kuba played before by Vilma Santos, mother of Luis Manzano who is her longtime bestfriend. After the teleserye, she was one of the lead roles of Maging Sino Ka Man opposites, Bea Alonzo, John Lloyd Cruz,and Sam Milby, her ex Boyfriend. Maging Sino Ka Man was followed by Maging Sino Ka Man: Book 2. Anne Curtis is known by the name Dyosa. She is the Philippine Goddess because her role is a goddess in the teleserye Dyosa opposites, Sam Milby, Luis Manzano,and Zanjoe Marudo. She was also the daughter of Ai Ai de las Alas in Ang Cute Ng Ina Mo. Love Interest of Aga Muhlach in When Love Begins, a block buster movie with Jericho Rosales in Baler, where she won best actress in MMFF 2008.
2008–2010: Continous television and film projectsIn 2008, Curtis starred in the film, When Love Begins, wherein she was paired with award-winning actor, Aga Muhlach. Later in that same year, she starred in the award-winning period film, Baler. This was her first on-sceen team-up with Jericho Rosales. She won the Best Actress Award from the 34th Metro Manila Film Festival. This marked as Curtis' first acting award, and was very thankful for it. She was also nominated in the 25th PMPC Star Awards for Movies as Film Actress of the Year and in the 11th Gawad Pasado Awards as Pinakapasadong Aktres.
Also in 2008, she got her second title role, Dyosa (Goddess). Curtis admitted that she was very nervous about her role and she picked that being a mermaid is the hardest. She had three leading men in the series, which are Sam Milby, Luis Manzano and Zanjoe Marudo. After this, she was dubbed as the "Dyosa" of Philippine Showbiz. In 2009, she was one of the main hosts of the highly popular morning variety show, Showtime alongside Vhong Navarro, Kim Atienza, Vice Ganda and many more. In 2009, she played the role of Candice in the television series, The Wedding. Her leading men were Zanjoe Marudo and Derek Ramsay. In 2010, she starred in the film Babe, I Love You. The movie marked her first big-screen team-up with ex boyfriend, Sam Milby. Her second movie for 2010 was In Your Eyes. Her co-stars include Claudine Barretto and her ex-boyfriend, Richard Gutierrez. Her role in this film earned her a Best Supporting Actress Award from the 29th Luna Awards and a Movie Actress of the Year Nominee from the 27th PMPC Star Awards for Movies.
2011: No Other Woman and Career expansion via AnnebisyosaIn 2011, Curtis starred in the Philippine adaptation of the Koreanovela Green Rose. The series featured her reunion with Jericho Rosales. In the same year, Curtis starred in the romantic-comedy film, Who's That Girl?. It served as her reunion movie with Luis Manzano. On September 23, 2011, Curtis launched her debut album, Annebisyosa, under Viva Records. She asked for her bosses to release her album, as it is one of her dreams. She described her album as "super fun" and "not serious." She also stated that people should listen at their own risk. On October 16, 2011, with less than a month of release, the album reached the gold status, as it sold 10,000 copies. Curtis cried while receiving the gold record award. On December 11, 2011, the album reached the Platinum status. In 2011, she played the role of Kara Zalderiaga in the phenomenal box-office hit, No Other Woman, which also stars Derek Ramsay and Cristine Reyes.
The film earned Php 275 Million, making it the highest grossing Filipino film, until it was beaten by The Unkabogable Praybeyt Benjamin. Her role in the film lead her and co-star Cristine Reyes to be recognized as the Box Office Queens at the Guillermo Mendoza Memorial Foundation's 43rd Box-Office Entertainment award. She also won as the Pinakapasadong Aktres (Best Actress) at the 14th Gawad Pasado Awards. In the 28th PMPC Star Awards for Movies, she was nominated as Movie Actress of the Year.